中国中西医结合杂志2012，Vol.32Issue(6)：774-778,5.
中西医结合治疗91例老年晚期非小细胞肺癌疗效观察
Clinical Study of Integrative Treatment for Ninety-one Elderly Patients with Advanced Non-small Cell Lung Cancer
摘要
Abstract
Objective To observe the effects of integrative therapy on elderly patients with advanced non-small cell lung cancer (NSCLC), thus providing clinical evidence for further studies. Methods Totally 91 elderly patients with advanced NSCLC were randomly assigned to three groups, i. e., the Chinese medicine (CM) group (Group I , 31 cases), the chemotherapy group (Group Ⅱ , 30 cases), and the CM and chemotherapy combination group (Group Ⅲ, 30 cases). Oral administration of CM decoction and intravenous dripping of Chinese patent medicine were given to patients in Group Ⅰ. Patients in Group JJ received chemotherapeutic protocol alone. Patients in Group in received chemotherapeutic protocol while taking CM decoction. Twenty-eight days were taken as one therapeutic course, and two courses in total. They were observed for two treatment courses by taking Symptoms Scale of CM to Primary Lung Cancer, bone marrow depression score,and progression-free survival (PFS) as therapeutic efficacy indices. Meanwhile, the Cox's proportional hazards regression model was established to analyze the favorable factors and risk factors that influenced patients' PFS. Results The CM symptom integral of Group Ⅰ and Group Ⅲ was superior to that before treatment, showing statistical difference (P<0.01). The occurrence of bone marrow depression in Group ID was lower than that in Group Ⅱ. The degree of bone marrow depression was also milder in Group JJJ than in Group Ⅱ , but there was no statistical difference in inter-group comparison (P=0.097,P=0. 299). The PFS was 202 days in Group Ⅲ, 168 days in Group I , and 129 days in Group Ⅱ. It was better in Group Ⅲ than in Group Ⅱ (P=0.0157). The Cox regression a-nalysis showed that positive factors to longer PFS included CM + chemotherapy, no surgical management, and PS =1. Conclusions CM therapy could improve the symptoms of elderly patients with advanced NSCLC. It might extend the PFS of the elderly patients by CM therapy combined with chemotherapy.关键词
中医药疗法/晚期非小细胞肺癌/老年患者/生活质量Key words
Chinese medicine therapy/ advanced non-small cell lung cancer/ elderly patient/ quality of life引用本文复制引用
游捷,单孟俊,赵慧,谭翔文..中西医结合治疗91例老年晚期非小细胞肺癌疗效观察[J].中国中西医结合杂志,2012,32(6):774-778,5.基金项目
老年肿瘤综合治疗策略研究(No.民人教科字[2008]47-2) （No.民人教科字[2008]47-2）
