安徽医科大学学报2012，Vol.47Issue(9)：1095-1098,4.
神经侵犯在Ⅱ期直肠癌患者中的预后意义
Prognostic value of perineural invasion in patients with stage Ⅱ rectal carcinoma
付大鹏 1龚旭晨 1孔长青2
作者信息
- 1. 安徽医科大学新疆临床学院,新疆维吾尔自治区人民医院肛肠外科,乌鲁木齐,830000
- 2. 安徽医科大学新疆临床学院,新疆维吾尔自治区人民医院普通外科,乌鲁木齐,830000
- 折叠
摘要
Abstract
Objective To investigate the prognostic value of perineural invasion ( PNI ) in patients with stage II
rectal carcinoma. Methods HE stained tissue sections from 194 patients who underwent radical resection of stage II rectal cancer were accessed and re-readed. The chi-square test was taken on PNI according to HE stain, and multivariable COX analysis was applied to analyse disease-free survival and overall survial. Results PNI was identified in 36 patients( 18. 5% ), only related with differentiation( P <0. 01 )and vascular invasion( P =0. 02 ) in the clinical and pathological characteristics , while did not relate with age , gender, depth of tumor invasion, tumor diameter. In the univariate analysis, factors associated with poorer disease free survival were depth of tumor invasion( P = 0. 149 ), number of lymph nodes harvested( P = 0. 052 ), vascular invasion( P = 0. 013 ), perineural invasion( P < 0. 001 ). Age( P = 0. 029 ), gender( P = 0. 063 ), location( P = 0. 063 ), number of lymph nodes harvested( P = 0. 028 )were related with worse over-all survival. Multivariate analysis revealed that PNI( P =0. 001 ) was the only independent prognostic factor for disease-free survival in 5 years, while the number of lymph nodes harvested( P = 0. 001 ) was the only independent prognostic factor for over-all survival. Conclusion Perineural invasion is the only independent prognostic factor for disease free survival which can be treated as an important reference in the prognosis of stage II rectal carcinoma. 关键词
直肠癌/预后/肿瘤浸润/神经侵犯Key words
rectal carcinoma/prognostic/trmor invasion/perineural invasion分类
医药卫生引用本文复制引用
付大鹏,龚旭晨,孔长青..神经侵犯在Ⅱ期直肠癌患者中的预后意义[J].安徽医科大学学报,2012,47(9):1095-1098,4.
