北京中医药大学学报2012，Vol.35Issue(2)：117-120,124,5.
酸枣仁汤组分配方对高架十字迷宫大鼠海马单胺类递质及其代谢物的影响
Influence of component formula of Suanzaoren Tang on hippocampus monoamine neurotransmitters and their metabolites in rats in elevated plus maze test
摘要
Abstract
Objective To observe the influence of component formula of Suanzaoren Tang on hippocampus monoamine neurotransmitters and their metabolites in rats in elevated plus maze test (EPM) , and discuss its effective components and mechanism of anti-anxiety. Methods The influence of component formula of Suanzaoren Tang on rat ethology was observed by using international common-used anxiety animal model in EPM. The levels of monoamine neurotransmitters including noradrenaline (NE) , 5-hydroxytryptamine (5-HT) and dopamine (DA) and their metabolites were detected by applying HPLC. Results Compared with blank group, the ratio of entering times and retention time ratio in open arm increased significantly in whole component formula group (whole CF group) , effective component formula group (effective CF group) and diazepam group (P <0. 01 or P <0. 05). The level of 5-HT decreased significantly in effective CF group and diazepam group, and showed a decreasing trend in whole CF group. The level of hippocampus homovanillic acid (HVA) increased significantly in effective CF group (P<0.01). Conclusion The whole component formula and effective component formula of Suanzaoren Tang are similar to diazepam in anti-anxiety mechanism to some extent, which may involve the decrease of hippocampus 5-HT level. The whole component formula and effective component formula have different influences on the metabolism of hippocampus monoamine neurotransmitters in rats.关键词
酸枣仁汤/有效组分/抗焦虑/高架十字迷宫/单胺类递质/大鼠Key words
Suanzaoren Tang/ effective components/ anti-anxiety/ elevated plus maze/ monoamine neurotransmitters/ rats分类
医药卫生引用本文复制引用
王守勇,谢鸣..酸枣仁汤组分配方对高架十字迷宫大鼠海马单胺类递质及其代谢物的影响[J].北京中医药大学学报,2012,35(2):117-120,124,5.基金项目
教育部“十五”期间211项目重点学科建设创新基金资助项目(No.BZY21103FJ03) （No.BZY21103FJ03）
