重庆医学2012，Vol.41Issue(23)：2352-2354,2357,4.DOI:10.3969/j.issn.1671-8348.2012.23.003
青蒿琥酯对Tca8113细胞的抑制作用及对RECK蛋白表达的影响
Growth inhibition of Artesunate on Tca8113 cell and its influence on RECK expression
摘要
Abstract
Objective To study the growth inhibition effect of artesunate on Tca8113 cells and its influence on RECK expression in vitro.Methods Different concentration ART stimulated Tca8113 cells,tested cells proliferation by MTT assay,tested cells apop-tosis and cell cycle by flow cytometry,wound healing test was used to measure the cells migration ability,RECK expression was detected by immunocytochemical methods.Results ART not only inhibited the proliferation but also induced apoptosis of Tca8113 cells,the two were all time-and dose-dependent.Cells cycle arrested at Go and Gi phase.ART could depress the migration ability of Tca8113 cells.High-dose ART could up-regulate the RECK expression.Conclusion ART could inhibit proliferation of Tca8113 cells in vitro,and possibly depressed migration ability of cells by up-regulating RECK expression.关键词
青蒿琥酯/Tca8113细胞/RECK/抑制Key words
Artesunate/Tca8113 cells/RECK/inhibition引用本文复制引用
周铁军,向丽,李健,贾春霞,王云,龚莉..青蒿琥酯对Tca8113细胞的抑制作用及对RECK蛋白表达的影响[J].重庆医学,2012,41(23):2352-2354,2357,4.基金项目
四川省教育厅重点项目基金资助项目(08ZA151). （08ZA151）
