重庆医学2012，Vol.41Issue(23)：2383-2385,3.DOI:10.3969/j.issn.1671-8348.2012.23.015
不同铂类联合紫杉烷在妇科恶性肿瘤化疗中的毒副反应对比分析
Comparative study of toxicity of chemotherapy regimen containing platinum combined with taxanes in patients with gynecological neoplasms
孙欣欣 1黄冬梅 1刘玉玲1
作者信息
- 1. 郑州大学第二附属医院妇产科,河南郑州,450014
- 折叠
摘要
Abstract
Objective Through comparing nedaplatin/taxane with oxaliplatin/taxane and carboplatin/taxane combination chemotherapy to understand the toxicity of nedaplatin combined chemotherapy regimen in patients with gynecological neoplasms.Methods From Jan.2010 to Oct.2011,133 patients with gynecological neoplasms were given chemotherapy regimen containing nedaplatin/ taxane or oxaliplatin/taxane or carboplatin/taxane.A comparative study of toxicity was made then among the three groups retrospectively.Results Nedaplatin group was lower than the oxaliplatin group in hemoglobin decrease,leukopenia,neutropenia with no statistical differences except for neutropenia,and also lower than carboplatin group with all no statistical differences(P>0.05).Nedaplatin group was higher than the oxaliplatin group in thrombopenia(41.49% ,29.52%) ,with statistical differences,and higher than carboplatin group(41.49%,34.35%) ,with no statistical differences(P>0.05).One patient was dead because of 4 grade rny-elosuppression induced infection.In nedaplatin group there was lower incidence in gastrointestinal toxicity than oxaliplatin group and carboplatin group with no statistical differences(P>0.05).There was no anaphylaxis,nephrotoxicity,fever appeared in nedaplatin group and a few patients had mild hepatic toxicity and neruotoxicity.Conclusion As a new generation anticancer drug,the main toxicity of nedaplatin was myelosuppression and gastrointestinal toxicity.There were no obvious differences in toxicity between nedaplatin and oxaliplatin^carboplatin in combined chemotherapy.Kither can be selected according to the patient s specific clinical situation.关键词
妇科肿瘤/奈达铂/奥沙利铂/卡铂/联合化疗/毒副反应Key words
gynecological neoplasm/nedaplatin/oxaliplatin/carboplatin/combined chemotherapy/toxicity引用本文复制引用
孙欣欣,黄冬梅,刘玉玲..不同铂类联合紫杉烷在妇科恶性肿瘤化疗中的毒副反应对比分析[J].重庆医学,2012,41(23):2383-2385,3.
