重庆医学2012，Vol.41Issue(23)：2386-2388,2391,4.DOI:10.3969/j.issn.1671-8348.2012.23.016
雌激素改善大鼠记忆及促进海马BDNF蛋白表达上调
Estrogen to improve rat memory and hippocampal BDNF protein expression upregulation
唐明山1
作者信息
- 1. 重庆市巴南区人民医院神经内科,401320
- 折叠
摘要
Abstract
Objective To explore the relation of estrogen on memory and expression of BDNF in hippocampus of postmenopaus-al rats.Methods Rats retired from breeding for two reproductive cycles ,15-month-old,and 350-400 g weight,were divided into two groups by random assigned method.Before testing ,estradiol benzoate and the same capacity of normal saline was injected subcuta-neouly on the cervical part of rats,memory of rats was detected by Morris water maze.RT-PCR and Western-blot wre respectively used to detect expression of BDNF mRNA,TrkB mRNA and protein of BDNF,TrkB and proBDNF hippocampus of postmenopausal rats.Results Compared with the control group,the rats of estrogen replacement therapy group showed a shorter escape latency (P<0.05) Contrasted to the control group,expression of BDNF,TrkB and proBDNF protein in hippocampus increased(P<0.05).Conclusion Memory is enhanced in the rats received estrogen replacement therapy group in postmenopausal rats ,it maybe related with high expression of BDNF and relational protein.关键词
雌激素/记忆/脑源性神经营养因子Key words
estrogen/memory/brain-derived nerve growth factor引用本文复制引用
唐明山..雌激素改善大鼠记忆及促进海马BDNF蛋白表达上调[J].重庆医学,2012,41(23):2386-2388,2391,4.
