重庆医学2012，Vol.41Issue(24)：2459-2461,封2,4.DOI:10.3969/j.issn.1671-8348.2012.24.002
乳腺癌组织MT1-MMP表达与淋巴管生成的关系
Relationship between MT1-MMP and Lymphangiogenesis in breast cancer
摘要
Abstract
Objective To investigate evidence of MT1-MMP involved in breast cancer lymphangiogenesis process,we study the correlation between expressions of MT1-MMP and VEGF-C,LMVD in breast cancer.Methods The expressions of MT1-MMP,VEGF-C and D2-40 in 87 patients with breast cancer were detected by immunohistochenical method,and the relationship between MT1-MMP,VEGF-C,LMVD and axillary lymph node metastasis were analyzed.Results MT1-MMP,VEGF-C positive expression and high LMVD were associated axillary lymph node metastasis.The positivity rate of VEGF-C was significantly higher in MT1-MMP positive patients than that in MT1-MMP negative ones(86.0% vs 43.2% ,P<0.01).The LMVD was significantly higher in MT1-MMP positive patients than that in MT1-MMP negative ones(30.2 vs 25.1 ,P<0.01).Conclusion The expressions of MT1-MMP is closely related to lymphangiogenesis and lymph node metastasis in breast cancer,and may be an important factor involved in breast cancer lymphangiogenesis.关键词
膜型基质金属蛋白酶-1/血管内皮生长因子C/微淋巴管密度/乳腺肿瘤Key words
MT1-MMP/VEGF-C/LMVD/breast cancer引用本文复制引用
姚广裕,何萍,杨名添,刘民锋,叶长生..乳腺癌组织MT1-MMP表达与淋巴管生成的关系[J].重庆医学,2012,41(24):2459-2461,封2,4.基金项目
国家"十五"科技攻关计划资助项目(2001BA703B04). （2001BA703B04）
