重庆医学2012，Vol.41Issue(24)：2469-2471,3.DOI:10.3969/j.issn.1671-8348.2012.24.005
加味养阴清肺汤防治急性放射性口腔炎的疗效及对细胞因子的影响
Effect on cytokines and clinical outcomes of treatment of acute radiation-induced stomatitis by Modified Yangyin Qingfei decoction
摘要
Abstract
Objective To investigate the effect on cytokines and clinical outcomes of treatment of acute radiation-induced stomatitis by Modified Yangyin Qingfei decoction.Methods 80 cases with a radical radiotherapy were divided into two groups randomly,40 cases in the treatment group and 40 cases in the controlled group.The treatment group was treated by Modified Yangyin Qingfei decoction after the initiation of radiotherapy.The controlled group was treated by the mouthwash after DT = 20 Gy.The incidence rates of stomatitis and the levels of IFN-γ,TNF-α,IL-2 ,IL-4 ,IL-6 ,IL-10 ,IL-1β and IL-8 in saliva were measured.Results With the increasing dose of radiotherapy,the incidence rates of HI "degree and I\r-degree stomatitis were significantly increased in the two groups(P<0.05).The incidence rate of the treatment group,however,was lower than that of the controlled group(P<0.05).The levels of cytokines in two groups indicated no differences before the initiation of radiotherapy(P>0.05).The levels of cytokines in two groups at DT = 40 Gy increased compared with previous radiotherapy,but the increase of cytokines was not obvious in the treatment group(P>0.05) ,and it was remarkably lower than that of the controlled group(P = 0.000).At DT=70 Gy,the increase of IL-10 was not obvious in treatment group compared with previous radiotherapy (P = 0.055) ,the level of IL-10 increased remarkably in the controlled group(P=0.000) ,and the level of IL-10 in treatment group was remarkably lower than that of the controlled group(P = 0.000) ;The level of IL-4 in the two groups were both lower than the previous radiotherapy(P = 0.000) ,The level of IL-4 in treatment group was significantly lower than that in the controlled group(P = 0.001) ;The levels of IFN-g,TNF-α,L-2 ,IL-6 in two groups were remarkably lower than those of the previous radiotherapy (P = 0.000).The levels of IL-2,IL-6 ,IL-1β,IL-8 in treatment group were lower than those in controlled group(P<0.05).Conclusion The acute radiation-induced stomatitis is significantly improved after prophylactic therapy of Modified Yangyin Qingfei decoction.The mechanism might be that the drug regulated the expression of multiple inflammatory cytokines.关键词
加味养阴清肺汤/放射性口腔炎/炎性细胞因子Key words
Modified Yangyin Qingfei decoction/radiation-induced stomatitis/inflammatory cytokines引用本文复制引用
沈红梅,黄杰,贾立群,周映伽,黄菁..加味养阴清肺汤防治急性放射性口腔炎的疗效及对细胞因子的影响[J].重庆医学,2012,41(24):2469-2471,3.基金项目
云南省自然科学基金资助项目(2009CD182) （2009CD182）
云南省卫生厅科技计划基金资助项目(2010NS086) （2010NS086）
云南省教育厅科学研究基金资助项目(07Y10626). （07Y10626）
