重庆医学2012，Vol.41Issue(24)：2472-2473,2476,3.DOI:10.3969/j.issn.1671-8348.2012.24.006
ROC曲线评价血清IGF-1在胶质瘤中的诊断价值
Evaluation of diagnostic value of IGF-1 in glioma by ROC analysis
摘要
Abstract
Objective To evaluate the diagnostic value of insulin-like growth factor-l(IGF-l)in glioma by ROC analysis.Methods 40 patients with glioma and 40 patients with non-glial originatied tumor were entered into the study as experimental groups,and 40 healthy volunteers served as control.IGF-1 was detected by KLISA and its results of three groups were compared.The diagnostic critical value of glioma was evaluated.Results There was no difference between non-glial originatied tumor group(37.77 + 46.29)μg/L and control group(26.98±27.63)μg/L(P>0.05).The IGF-1 in glioma group(643.13±792.19)μg/L was higher than that in non-glial originatied tumor group combined with control group(63.52±101.53)μg/L(P<0.01).ROC curve analysis showed that the area under curve was 0.831(95%CI 0.745- 0.917) ,the diagnostic critical value was 110.425 μg/L,the sensitivity,specificity,predicted value of positive,predicted value of negative,correct rate and Youden s index were 90.0% ,92.3% ,87.5% ,92.3% ,90.5% and 82.3% respectively.Conclusion IGF-1 may be regarded as a diagnostic index of glioma for its high sensitivity and specificity.关键词
胶质瘤/IGF-1/ROC曲线Key words
IGF-1/glioma/ROC curve引用本文复制引用
胡建刚,晏怡,覃川,李柏成,张彪,张正保,杨秀江..ROC曲线评价血清IGF-1在胶质瘤中的诊断价值[J].重庆医学,2012,41(24):2472-2473,2476,3.基金项目
重庆市卫生局医学科研项目(2010-2-447). （2010-2-447）
