重庆医学2012，Vol.41Issue(25)：2575-2576,2580,3.DOI:10.3969/j.issn.1671-8348.2012.25.003
Tim-4基因rs7700944位点多态性与宁夏回族人群RA的关联性分析
Correlation between rs7700944 SNP of Tim-4 gene and rheumatoid arthritis in Ningxia Hui ethnicity
摘要
Abstract
Objective To investigate the correlation between rs7700944 SNP of Tim-4 gene and rheumatoid arthritis(RA) in Ningxia Hui ethnicity to provide theoretic basis for taking early prevention of RA. Methods The polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) genotyping method was carried out to examine SNP at rs7700944 site in Tim-4 gene,including 210 Ningxia Hui RA patients and 198 ethnically matched non-arthritis(non-RA) controls. Results The statistical analysis demonstrated the genotype and allele (χ2 =29. 051 and 14. 106 , P<0. 01). A allele was more frequent in the non-RA Hui individuals than that without RA,and OR(95%CI) value was 0. 549(0. 400 - 0. 752). In contrast,G allele was less common in Hui non-RA individuals than that in RA patients,and OR(95%CI) value was 1. 823(1. 330 - 2. 498)(P<0. 01). Conclusion rs7700944 polymorphism of Tim-4 gene may be strongly associated with RA susceptibility in Ningxia Hui ethnicity. G allele is the risk factor of RA and A allele is the protective factor of RA in Ningxia Hui ethnicity.关键词
多态性,限制性片段长度/等位基因/关节炎,类风湿/Tim-4基因Key words
polymorphism,restriction fragment length/alleles/arthritis,rheumatoid/Tim-4 gene引用本文复制引用
徐金瑞,杨易,周晶,孙晶莹..Tim-4基因rs7700944位点多态性与宁夏回族人群RA的关联性分析[J].重庆医学,2012,41(25):2575-2576,2580,3.基金项目
宁夏科技厅自然科学基金资助项目(NZ0933). （NZ0933）
