重庆医学2012，Vol.41Issue(26)：2746-2748,后插2,4.DOI:10.3969/j.issn.1671-8348.2012.26.027
促红细胞生成素和甲基泼尼松龙对大鼠急性脊髓损伤的疗效比较
Comparison of curative effects between erythropoietin and methylprednisolone for acute spinal cord injured rats
占乐云 1方海滨 1吕恩1
作者信息
- 1. 三峡大学人民医院麻醉科,湖北宜昌,443000
- 折叠
摘要
Abstract
Objective To investigate the neuroprotective effect of erythropoietin(EPO) and methylprednisolone(MP) for rat a-cute spinal cord injury (ASCI). Methods The incomplete ASCI rat model was established according to the improved Allen s method. 60 male rats were randomly divided into the EPO group, MP group and control group,20 cases in each group. The samples of spinal cord were taken at the time points of 8 h,24 h,3 d and 7 d after spinal cord injury. The motor function scores,count of apop-tosis cells and the pathological change of spinal cord were compared among the three groups at corresponding time points. Results There was no statistical difference in the average scores at 2,8,24 h after injury,and the count of apoptosis cells at 8,24 h after injury between the EPO group and the MP group(P>0. 05), but both of them were better than those in the control group(P< 0. 01). At 3,7d after injury, the motor function scores and count of apoptosis cells were superior to those in the MP group(P< 0. 05) and significantly superior to those in the control group(P<0. 01). Conclusion EPO has stronger and more persistent anti-apoptosis effect,can significantly alleviate secondary spinal cord injury and promote recovery of motor function.关键词
泼尼松龙/脊髓损伤/红细胞生成素/细胞凋亡/大鼠Key words
prednisolone/spinal cord injuries/erythropoietin/apoptosis/rats引用本文复制引用
占乐云,方海滨,吕恩..促红细胞生成素和甲基泼尼松龙对大鼠急性脊髓损伤的疗效比较[J].重庆医学,2012,41(26):2746-2748,后插2,4.
