中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(9)：513-516,4.DOI:10.1007/s10330-012-1038-1
放疗诱导人肝细胞癌上皮-间质转化
Induction of epithelial-mesenchymal transition(EMT) in human hepatocellular carcinoma after radiotherapy
摘要
Abstract
Objective: Epithelial-mesenchymal transition (EMT) is a critical early event for the invasion and metastasis of many carcinomas. In the present study, we examined EMT markers in the residual cancer cells of hepatocellular carcinoma (HCC) after radiotherapy. Methods: Eight patients with large HCC who underwent hepatectomy with preoperative radiotherapy were studied. The expressions of E-cadherin and vimentin were determined immunohistochemically in the residual cancer cells of HCC following radiotherapy, and also in the pre-radiotherapy biopsy cancer cells. Results: Histological analysis showed that some residual cancer cells of HCC displayed an elongated spindle or fibroblast-like shape. The expression of Ecadherin was markedly reduced or negative in the spindle residual cancer cells, but the expression of vimentin significantly induced.However, the above changes were not found in the pre-radiotherapy biopsy cancer cells. Conclusion: EMT is induced in the residual cancer cells of HCC following radiotherapy, which may facilitate the systemic dissemination of cancer cells.关键词
epithelial-mesenchymal transition (EMT)/radiotherapy/residual cancer cells/hepatocellular carcinoma (HCC)Key words
epithelial-mesenchymal transition (EMT)/radiotherapy/residual cancer cells/hepatocellular carcinoma (HCC)引用本文复制引用
Ximing Xu,Junjian Deng,Guangjin Yuan,Miao Xiang,Biao Chen,Jiao Yang,Yiqiao Zhang,Lei Shi,Zuguo Li..放疗诱导人肝细胞癌上皮-间质转化[J].中德临床肿瘤学杂志（英文版）,2012,11(9):513-516,4.基金项目
Supported by grants from the Natural Science Foundation of China (No.81000998) and New Teachers Foundation of Ministry of Education ofChina (No.20090141120003). （No.81000998）
