中德临床肿瘤学杂志（英文版）2012，Vol.11Issue(9)：544-547,4.DOI:10.1007/s10330-012-1031-8
小剂量周方案单药司莫司汀治疗伴有广泛皮下转移的MGMT甲基化阳性的非特异性外周T细胞淋巴瘤1例报道
Weekly low-dose Semustine in a patient with peripheral T-cell lymphoma, not otherwise specified(PTCL-NOS) coupled with subcutaneous involvement and positive O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation
Wei Ren 1Baorui Liu 1Li Xie 1Jing Yan 1Weiwei Kong 1Yang Yang 1Lijing Zhu 1Wenjing Hu 1Xinyun Xu 2Xiaoping Qian1
作者信息
- 1. Comprehensive Cancer Center of Drum Tower Hospital, Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
- 2. Department of Pathology,Drum Tower Hospital,Nanjing 210008,China
- 折叠
摘要
Abstract
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with no treatment consensus and poor prognosis. We herein described an extraordinary refractory case of PTCL-NOS with widely involvement of subcutaneous tissue, which showed an excellent response to Semustine personalized chemotherapy based on the detection finding of positive O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. This is the first english report to indicate that single nitrosourea agent such as Semustine may have good efficacy and safety for widespread subcutaneous involvement of PTCL-NOS with positive MGMT promoter methylation.关键词
peripheral T-cell lymphoma(PTCL)/Semustine/chemotherapy/O6-methylguanine-DNA methyltransferase promoter methylation(MGMT)Key words
peripheral T-cell lymphoma(PTCL)/Semustine/chemotherapy/O6-methylguanine-DNA methyltransferase promoter methylation(MGMT)引用本文复制引用
Wei Ren,Baorui Liu,Li Xie,Jing Yan,Weiwei Kong,Yang Yang,Lijing Zhu,Wenjing Hu,Xinyun Xu,Xiaoping Qian..小剂量周方案单药司莫司汀治疗伴有广泛皮下转移的MGMT甲基化阳性的非特异性外周T细胞淋巴瘤1例报道[J].中德临床肿瘤学杂志（英文版）,2012,11(9):544-547,4.
