南方医科大学学报2012，Vol.32Issue(6)：794-797,4.DOI:10.3969/j.issn.1673-4254.2012.06.008
TMEM16A在胃腺癌中的表达及意义
Expression of TMEM16A in gastric carcinoma and its clinical implications
摘要
Abstract
Objective To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications- Methods A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.Results TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells.Of the 72 specimens of the tumor tissues,the total positivity rate of TMEM16A expression was 80-56% (58/72),significantly higher than the rate in the adjacent tissues (4.17%,3/72,P<0.005}.Conclusion Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases.TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.关键词
胃癌/Ca2+激活的氯离子通道/TMEM16A/免疫组织化学Key words
gastric carcinoma/Ca2+-activated Cl- channels/TMEM16A/immunohistochemistry分类
医药卫生引用本文复制引用
杨军,刘妮,康安静,靳耀锋,王军宁,苏宝山,陈晓黎,李宗芳..TMEM16A在胃腺癌中的表达及意义[J].南方医科大学学报,2012,32(6):794-797,4.基金项目
国家自然科学基金(NSFC30872403) （NSFC30872403）
教育部新世纪优秀人才计划(NCET-10-0647) （NCET-10-0647）
教育部"长江学者和创新团队发展计划"创新团队(IRT1171) （IRT1171）
