南方医科大学学报2012，Vol.32Issue(6)：890-893,4.DOI:10.3969/j.issn.1673-4254.2012.06.030
阿西替尼联合5-FU对移植人肠癌细胞的裸鼠的治疗作用
Therapeutic effect of axitinib and 5-FU in nude mice bearing human colon cancer xenograft
摘要
Abstract
Objective To study the inhibitory effect and toxicity of axitinib combined with 5-FU in nude mice bearing transplanted tumor of colon cancer LoVo cells.Methods Nude mouse models bearing LoVo colon cancer xenograft were randomized into vehicle control group,untreated control group,axitinib-treated group,5-FU-treated group and combined treatment group for corresponding treatments.The tumor dimensions,body weight and tumor weight were recorded,and the efficacy and toxicity were evaluated interms of complete remission (CR),partial remission (PR),tumor growth delay (TGD),mortality rate and net body weight loss.Results The combined treatment showed a significantly stronger efficacy than axitinib or 5-FU used alone.TGD of the combined treatment group was 16.73 days,longer than that of axitinib (8.53 days) and 5-FU (9.72 days) used alone.No mouse died during the treatments in the untreated control group,and 1 died in each of the other 4 groups.The mortality rate and weight loss were both less than 20%.One mouse had PR in axitinib-treated group and another in the combination treatment group.Axitinib,alone and in combination with 5-FU,reduced ABCG2 expression in the tumor tissue,and 5-FU has no such effect.Conclusion Combination of axitinib and 5-FU produces better antitumor effect than either drug used alone and is well tolerated in nude mice bearing colon cancer xenograft.关键词
阿西替尼/5-FU/肠癌Key words
axitinib/5-FU/colon cancer分类
医药卫生引用本文复制引用
赵佳,招婷,谢锋伟,何本夫..阿西替尼联合5-FU对移植人肠癌细胞的裸鼠的治疗作用[J].南方医科大学学报,2012,32(6):890-893,4.基金项目
广东省自然科学基金(S2011040003476) （S2011040003476）
广东省卫生厅(A2011277) （A2011277）
