南方医科大学学报2012，Vol.32Issue(6)：897-900,4.DOI:10.3969/j.issn.1673-4254.2012.06.032
椎间盘退变的形态学分型中转化生长因子-β1表达的临床意义
Association of transforming growth factor-β1 with pathological grading of intervertebral disc degeneration
摘要
Abstract
Objective: To explore the role of transforming growth factor-β1 (TGF-βl) in intervertebral disc degeneration and its association with the pathological grading of disc degeneration.Methods Normal and degenerative intervertebral disc tissues were collected were classified into 5 grades of increasing degenerative changes.HE staining,immunohistochemistry,TUNEL staining and RT-PCR were used to detect the expression of TGF-βl in the disc tissues.Results Immunohistochemistry and RT-PCR showed positive expressions of TGF-β1 and Bcl-2 in normal disc tissues,where Bax was expressed at have a trace level.In the degenerative disc tissues,TGF-βl expression increased with the pathological grades;the expression levels of TGF-p 1 showed significant differences between degenerative and normal tissues and between grade IV and grade I disc tissues (P< 0.01).Conclusion TGF-βl is an important factor participating in the disc degeneration and its expression level is closely related to the pathological grade of degenerative discs.关键词
椎间盘退变/形态学分型/发病机制Key words
intervertebral discs/degeneration/transforming growth factor-β1分类
医药卫生引用本文复制引用
杨旸,何晓峰,李彦豪,冯建宇,庞桦进,王江云,刘庆..椎间盘退变的形态学分型中转化生长因子-β1表达的临床意义[J].南方医科大学学报,2012,32(6):897-900,4.基金项目
广东省科技计划项目(2009B030801203) （2009B030801203）
