法医学杂志2012，Vol.28Issue(3)：167-171,5.DOI:10.3969/j.issn.1004-5619.2012.03.002
血清总IgE、类胰蛋白酶和类糜蛋白酶在药物过敏性休克死亡鉴定中的应用
Application of Serum Total IgE, Tryptase and Chymase in the Identification of Death Caused by Drug Anaphylactic Shock
摘要
Abstract
Objective To explore the application value of serum total IgE, tryptase and chymase in the identification of death caused by drug anaphylactie shock. Methods The general information from 235 cases of non-drug anaphylactic shock and 32 cases of drug anaphylactic shock were analyzed. The serum IgE level had been detected in the cases. Ten cases caused by coronary disease and 10 cases caused by sudden manhood death syndrome were selected from non-drug anaphylactic shock cases for the control group. Expressions of tryptase and chymase in the lung and heart were detected using immunohistochemislry method. The number and IOD of positive mast cells were counted. Results In the drug anaphylactic shock group, the IgE value of 18 samples(56.25%) was significantly higher than the normal upper limit of 120 IU/mL. In the non-drug anaphylactic shock group, the IgE value of 67 samples(28.51%) was higher than 120 IU/mL. The expressions of tryptase and chymase were significantly increased in lung and myocardial tissue in drug anaphylactic shock group (P<0.05). Conclusion Tryptase and chymase are more superior than that of the serum total IgE in the diagnosis of death caused by drug anaphylactic shock, and are more suitable in forensic practice.关键词
法医病理学/过敏反应/免疫球蛋白E/类胰蛋白酶/类糜蛋白酶Key words
forensic pathology/ anaphylaxis/ immunoglobulin E/ tryptase/ chymase分类
社会科学引用本文复制引用
王红杰,权力,罗斌,宋纬平,阳宇,黄京璐,郝博,高迪,汤大为,王小广,刘水平..血清总IgE、类胰蛋白酶和类糜蛋白酶在药物过敏性休克死亡鉴定中的应用[J].法医学杂志,2012,28(3):167-171,5.基金项目
国家自然科学基金资助项目(39700167) （39700167）
