广东医学2012，Vol.33Issue(13)：1863-1866,4.
柚皮苷对实验性2型糖尿病心肌病大鼠模型糖脂代谢的影响
Effects of naringin on glucose and lipids metabolism in rats with diabetic cardiomyopathy
摘要
Abstract
Objective To evaluate the effects of naringin on glucose and lipids metabolism in rats with diabetic cardiomyopathy. Methods Wister rats were randomized into normal control group, model control group, pioglitazon treatment group, and high, moderate and low dosage naringin treatment groups. Experimental rat model of type 2 diabetic cardiomyopathy was constructed by high sucrose-high fat diet and low dose streptozotocin peritoneal injection. After 4 weeks, saline, pioglitazon, and high, moderate and low dose naringin were given to corresponding rats for 6 consecutive weeks. Results Compared with model control group, the plasma levels of FBG, FINS, GSP, HOMA -IR, TG, TC, LDL-C and FFA were significantly elevated in the other 4 groups ( P < 0. 05 ), while significant reduction of weight and BMI was also revealed ( P <0. 05 ). Equivalent improvement in glucose metabolism and even significantly higher efficacy in lipid metabolism were revealed in high dose naringin treatment group when comparing with those in pioglitazon treatment group ( P < 0. 05 ). Conclusion Naringin can improve the cardiac muscle function of diabetic cardiomyopathy rats via regulation of glucolipid metabolism and reduction of obesity.关键词
柚皮苷/糖尿病/心肌疾病/血糖/血脂Key words
naringin/ diabetic mellitus/ cardiomyopathy/ blood glucose/ blood lipids引用本文复制引用
吴铿,游琼,黄瑞娜,梁建光,涂焰明..柚皮苷对实验性2型糖尿病心肌病大鼠模型糖脂代谢的影响[J].广东医学,2012,33(13):1863-1866,4.基金项目
广东省自然科学基金资助项目(编号:s2011010002620) （编号:s2011010002620）
