广东医学2012，Vol.33Issue(13)：1903-1905,3.
过氧化物酶体增殖物激活受体γ在反流性食管炎、Barrett食管和食管腺癌中的表达
The expression of PPARγ in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma
摘要
Abstract
Objective To investigate the PPARγ expression and cell proliferation in reflux esophagitis ( RE ), Barrett esophagus ( BE ) and esophageal adenocarcinoma ( EA ). Methods The expression of PPARγ and PCNA were determined by immunohistochemistry technique and Western blot in patients with RE, BE and EA, and the normal controls , of which the esophageal mucous membrane biopsy were obtained by gastroscopy. Results The PPARγ positive rates in RE, BE and EA were 25% , 30% and 33. 3% , respectively; significantly higher than that in normal controls ( 10% , P <0. 05 ). Moreover, the PPARγ protein absorbance ratios in RE, BE and EA were 0. 28 ±0. 15, 0. 21 ±0. 18 and 0. 32 ± 0. 13 , respectively; significantly higher than that in normal controls ( 0. 08 ± 0. 06, P < 0. 05 ). However, there was no significant difference among RE, BE and EA groups in PPARγ expression. The PCNA positive rates in RE, BE, EA and control groups were 25% , 60% , 75% and 100% , respectively. Conclusion There are the progressing cell proliferation and up - regulation of PPARγ protein while the malignancy progression of esophagus, suggesting PPARγ is involved in the cell proliferation regulation in the pathogenesis of reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.关键词
反流性食管炎/Barrett食管/食管腺癌/过氧化物酶体增殖物激活受体γKey words
reflux esophagitis/ Barrett esophagus/ esophageal adenocarcinoma/ peroxisome proliferators activited receptor γ引用本文复制引用
姜志茹,陈静,郭海,郑爱萍..过氧化物酶体增殖物激活受体γ在反流性食管炎、Barrett食管和食管腺癌中的表达[J].广东医学,2012,33(13):1903-1905,3.基金项目
广东省深圳市科技计划项目(编号:200903074) （编号:200903074）
