广东医学2012，Vol.33Issue(16)：2379-2382,4.
三甲基氯化锡对脉络丛钠-钾-ATP酶活性的影响
The inhibitive effects of trimethyltin chloride on Na+- K+-ATPase activity on choroid plexus epithelial cells in rats
摘要
Abstract
Objective To study the inhibitive effects of trimethyltin chloride ( TMT ) on the activity of Na+-K+ - ATPase ( NKA ) on choroid plexus epithelial cells in SD female rats. Methods The rats in treatment groups were in-traperitoneally injected with TMT ( 10 mg/kg ) and sacrificed after 1 h, 24 h, 36 h, 48 h and 72 h, respectively. The NKA activity on the choroid plexus epithelial cells and serum K+ were assessed. Cerebrospinal fluids ( CSF ) were collected for assessment of Na+ , Cl- ions and glucose concentrations, while the morphological observation of the choroids plexus was carried out in optical microscope. Results Sustained hypokalemia and neurological damage symptoms were presented after TMT poisoning. The decrease of serum K+ was consistent with the reduction of NKA activitiy on choroid plexus. Significant elevation of glucose was observed at 24 h and 36 h, with significant descence of CSF K+ revealed at 48 h. No morphological change was observed in choroid plexus epithelial cells under light microscope. Conclusion The TMT inhibits the activity of NKA on choroid plexus, so as to induce CSF electrolyte imbalance, suggesting a posible mechanism of TMT-induced central nerve system injury.关键词
三甲基氯化锡/脉络丛/钠-钾-ATP酶Key words
trimethyltin chloride/ choroid plexus/ Na+ -K+ -ATPase引用本文复制引用
赖关朝,杨子,武昕,高洪彬,刘晓勇,唐小江..三甲基氯化锡对脉络丛钠-钾-ATP酶活性的影响[J].广东医学,2012,33(16):2379-2382,4.基金项目
国家自然科学基金资助项目(编号:30771786、 30972458),广东省医学科研基金资助项目(编号:B2007012) （编号:30771786、 30972458）
