广东药学院学报2012，Vol.28Issue(3)：242-245,4.DOI:10.3969/j.issn.1006-8783.2012.03.004
司帕沙星阳离子脂质体原位凝胶兔角膜滞留性考察
In vivo rabbit corneal retention of ocular sparfloxacin cationic liposomal in-situ gels
刘榜荣 1黄理 2何文2
作者信息
- 1. 保康县人民医院药剂科,湖北襄樊441600
- 2. 武汉大学人民医院 药学部,湖北武汉430060
- 折叠
摘要
Abstract
Objective To investigate the rabbit comeal retention of ocular cationic liposomal in-situ gels(ISC) containing sparfloxacin(SF). Methods SF liposomes( SFL) were prepared by pH gradient method followed by N-trimethyl chitosan(TMC60) coating(TMC60-SFL). Poloxamer 407 was used as the base of the ISG mixed with TMC60-SFL to obtain TMC60-SFL-ISG. The residence in rabbit eyes was observed with fluorescence tracer method and compared with that of SFL.TMC60-SFL and SFL-ISG without TMC60-coating. The eye irritation of TMC60-SFL-ISG and SFL-ISG was studied as well. Resnlts Compared with that of SFL, the corneal retention time of TMC60-SFL showed no significant change,while that of SFL-ISG without TMC60-coating and TMC60-SFL-ISG was prolonged significantly(P <0.05) ,and the retention time of TMC60-SFL-ISG was the longest with notable differences with that of SFL-ISG without TMC60-coating(P <0. 05). Compared with the blank ISG, TMC60-SFL-ISG and SFL-ISG showed no significant irritation to the rabbit eyes. Conclusion TMC60-SFL-ISG show the advantages of cationic liposomes and ISG with prolonged comeal retention, which are valuable to be studied further. 关键词
司帕沙星/阳离子脂质体/原位凝胶/眼滞留性Key words
sparfloxacin/ cationic liposomes/ in-situ gels/ comeal retention分类
药学引用本文复制引用
刘榜荣,黄理,何文..司帕沙星阳离子脂质体原位凝胶兔角膜滞留性考察[J].广东药学院学报,2012,28(3):242-245,4.
