广东药学院学报2012，Vol.28Issue(3)：311-315,5.DOI:10.3969/j.issn.1006-8783.2012.03.020
大黄蟅虫超微粉剂对肝肾纤维化大鼠血液流变学的影响
Effects of ultramicro-powder of Dahuang Zhechong recipe on hemorheology of rats with hepatic fibrosis and renal interstitial fibrosis
摘要
Abstract
Objective To investigate the effect of ultnunicro-powder of Dahuang Zhechong recipe( DHZC) on hemorheology of rats with hepatic fibrosis and renal interstitial fibrosis. Methods DHZC were processed by ultramicro pulverization technology. The hepatic fibrosis model was produced by intraperitoneal injection of porcine serum. The renal interstitial fibrosis model was induced by unilateral ureter obstruction. SD rats were randomly divided into six groups,including the normal group, the sham operation group,two model groups and two DHZC-treated groups. The levels of serum HA, LN, PC III, IV-C and indexes of hemorheology were measured. Liver and kidney histopathology were examined. Results The contents of HA,LN,PC III, IV-C and indexes of hemorheology increased significantly in two model groups, while markedly decreased when treated with ultramicro-powder of DHZC. The histopathological analysis suggested that DHZC obviously alleviated the degree of hepatic fibrosis, renal interstitial fibrosis and tubular damage. Conclusion Ultramicro-powder of DHZC can effectively prevent hepatic fibrous and renal interstitial fibrosis in rats. The improvement of hemorheology and microcirculation is one of the benefits of DHZC to exert its anti-fibrosis effect.关键词
大黄蟅虫超微粉剂/免疫性肝纤维化/肾间质纤维化/血液流变学Key words
Dahuang Zhechong recipe/ immunity hepatic fibrosis/ renal interstitial fibrosis/ hemorheology分类
医药卫生引用本文复制引用
华何与,吕志平,张红栓,刘莉..大黄蟅虫超微粉剂对肝肾纤维化大鼠血液流变学的影响[J].广东药学院学报,2012,28(3):311-315,5.基金项目
广东省中医药局科研基金(20111269) （20111269）
