广东药学院学报2012，Vol.28Issue(3)：316-318,3.DOI:10.3969/j.issn.1006-8783.2012.03.021
毛橘红总黄酮对酒精性肝损伤大鼠肝细胞凋亡的影响
Effects of total flavonoids of Exocarpium Citri Grandis on hepatocyte apoptosis in rats with alcoholic hepatic injury
摘要
Abstract
Objective To study the effects of total flavonoids of Exocarpium Citri Grandis on hepatocyte apoptosis in rats with alcoholic hepatic injury. Methods Animal model of alcoholic liver damage in rats was established by intragastric administration. Male rats were randomly divided into six groups,including the negative group,the model group,the positive group,and three treatment groups with different dosages of total flavonoids of Exocarpium Citri Grandis. After four weeks,liver tissues were extracted and made single-cell suspensions. The rate of hepatocyte apoptosis was detected by flow cytometry. Results Compared with the negative group,apoptotic rate was increased in the model group(P<0.01) ,but the increased apoptotic rate was reduced when treatment with high-dosage of total flavonoids of Exocarpium Citri Grandis. Conclusion Total flavonoids in Exocarpium Citri Grandis can inhibit hepatocyte apoptosis and exert protective effect against alcoholic hepatic injury.关键词
毛橘红/总黄酮/酒精性肝损伤/细胞凋亡/大鼠Key words
Exocarpium Citri Grandis/ total flavonoids/alcoholic hepatic injury/ apoptosis/ rats分类
医药卫生引用本文复制引用
肖凤霞,邓韬,邓少东,邓超明,张旭倩,林励..毛橘红总黄酮对酒精性肝损伤大鼠肝细胞凋亡的影响[J].广东药学院学报,2012,28(3):316-318,3.基金项目
国家科技部"十二五"科技支撑计划项目(2011BAI01B02) （2011BAI01B02）
广州中医药大学科研基金项目(06C80) （06C80）
