国际口腔医学杂志2012，Vol.39Issue(5)：672-674,3.DOI:10.3969/j.issn.1673-5749.2012.05.031
肿瘤坏死因子受体相关因子联合核因子-κB激酶结合激酶1和干扰素刺激因子基因在介导DNA疫苗免疫中的作用
The role of tumor necrosis factor receptor-associated factor nuclear factor-κB-binding kinase 1 and stimulator of interferon genes mediated immune responses to DNA vaccines
摘要
Abstract
Tumor necrosis factor receptor-associated factor nuclear factor-KB-binding kinase 1 (TBK1) are already proved to play an important role in mediating immune responses to DNA vaccines, not only adaptive immune responses including cellular immunity and humoral immunity, but also innate immune responses. Recently, it is reported that stimulator of interferon genes (STING) is a significant element for the production of type I interferon to regulate innate immunity, which is mediated by TBK1. In this review, the role of TBK1 mediated immune responses to DNA vaccines and the role of STING gene mediated innate immune responses to TBK1 were introduced.关键词
DNA疫苗/肿瘤坏死因子受体相关因子联合核因子-κB激酶结合激酶/固有免疫/干扰素刺激因子基因Key words
DNA vaccine/ tumor necrosis factor receptor-associated factor nuclear factor-KB-binding kinase/ innate immunity/ stimulator of interferon genes分类
生物科学引用本文复制引用
宿凌恺..肿瘤坏死因子受体相关因子联合核因子-κB激酶结合激酶1和干扰素刺激因子基因在介导DNA疫苗免疫中的作用[J].国际口腔医学杂志,2012,39(5):672-674,3.基金项目
中央高校基本科研业务费专项资金资助项目(201130402020005) （201130402020005）
