国际病理科学与临床杂志2012，Vol.32Issue(2)：99-103,5.DOI:10.3969/j.issn.1672-7347.2012.02.002
P63,CK5/6,TTF1和napins A联合检测在肺鳞癌和肺腺癌鉴别诊断中的价值
Value of combined assay of p63, CK5/6, TTF 1, and napsin A in differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma
田华 1梅霞 1黄文斌 2张同海 2王劲松2
作者信息
- 1. 江都市人民医院病理科,江苏江都225200
- 2. 南京医科大学附属南京第一医院病理科,南京210006
- 折叠
摘要
Abstract
Objective: To explore the value of p63, cytokeratin 5/6(CK5/6), thyroid transcription factor-1(TTFl), and napsin A in the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma. Methods: The immunohistochemical EnVision technique was used to assay the expression of p63, CKS/6, TTF1 and napsin A in 42 patients with lung squamous cell carcinoma and 42 patients with lung adenocarcinoma. The sensitivity and specificity of measurement of p63, CK5/6, TTF1 and napsin A in the diagnosis of lung squamous cell carcinoma and lung adenocarcinoma were also analysed. Results: p63 and CK5/6 were expressed 100% and 97.6%, respectively, of lung squamous cell carcinomas examined, both of which were higher than those in lung adenocarcinoma (P<0.0l). The incidence of positive expression of TTF1 and napsin A in lung adenocarcinoma were 97.6% and 100%, higher than those in lung squamous cell carcinoma (P<0.0l). The sensitivity and specificity of p63 and CK5/6 for the diagnosis of lung squamous cell carcinoma were 100% and 92.9%, respectively. The
sensitivity and specificity of TTF1 and napsin A for the diagnosis of lung adenocarcinoma were 97.6% and 100%, respectively. Conclusion: The combined assay for p63,CK5/6,TTFl, and napsin A may be helpful for the differential diagnosis of lung squamous celt carcinoma and lung adenocarcinoma.关键词
肺肿瘤/鳞状细胞癌/腺癌/p63/CK5/6/TTF1/napsin AKey words
lung neoplasm/ squamous cell carcinoma/ adenocarcinoma/ p63/ cytokeratin 5/6/ thyroid transcription factor-1/
napsin A引用本文复制引用
田华,梅霞,黄文斌,张同海,王劲松..P63,CK5/6,TTF1和napins A联合检测在肺鳞癌和肺腺癌鉴别诊断中的价值[J].国际病理科学与临床杂志,2012,32(2):99-103,5.
