国际病理科学与临床杂志2012，Vol.32Issue(2)：180-184,5.DOI:10.3969/j.issn.1672-7347.2012.02.018
水通道蛋白-1在急性肾损伤中的作用
Role of aquaporin-1 in acute kidney injury
安宇 1李学军1
作者信息
- 1. 北京大学医学部基础医学院药理学系,北京 100191
- 折叠
摘要
Abstract
Acute kidney injury, with high morbidity and mortality, is a severe threat to health and life of patients. Aquaporin-1 is a kind of channel protein expressed abundantly in renal proximal tubular epithelial cells. The level of aquaporin-1 dramatically changes during the process of acute kidney injury, and, after a treatment of renoprotective drugs, it returns to a normal level. Studies on the mechanism suggest that aquaporin-1 plays a potent protective role in acute kidney injury by participating in migration of epithelial cells and by regulating epithelial-mesenchymal transition. Aquaporin-1 as a putative target might provide a novel lead in discovering drugs for acute kidney injury.关键词
急性肾损伤/急性肾衰竭/水通道蛋白-1/细胞迁移/上皮间质转化Key words
acute kidney injury/ acute renal failure/ aquaporin-1/ migration/ epithelial-mesenchymal transition引用本文复制引用
安宇,李学军..水通道蛋白-1在急性肾损伤中的作用[J].国际病理科学与临床杂志,2012,32(2):180-184,5.
