国际病理科学与临床杂志2012，Vol.32Issue(3)：216-221,6.
乳头浸润性汗管瘤样腺瘤临床病理分析
Clinicopathological analysis of infiltrating syringomatous adenoma of the nipple
摘要
Abstract
Objective: To study the clinicopathological features of infiltrating syringomatous adenoma of the nipple (ISAN). Methods: Ihe clinical, histopathological, and immunohistochemical findings of a case of ISAN were described, along with a review of the relevant literature. Results: The tumor was located in subcutis of the right nipple. Histopathologically, ISAN was composed of nests and cords of cells forming tubular structures, which infiltrated the stroma between smooth muscle bundles. These tubules were lined by two layers of cells and had a "comma" or "tadpole" shape. Keratotic microcysts were presented. Immunohistochemical test showed focally positive for cytokeratin, cytokeratin 5/6, CAM5.2, P63, and smooth muscle actin, but negative for estrogen receptor, progesterone receptor, CerbB2, cytokeratin 8/18, P53 and gross cystic disease fluid protein-15. Conclusion: ISAN is a rare benign tumor, which is often confused with some mimic carcinomas of the breast. Both pathologists and clinicians should know its clinicopathological features to avoid misdiagnosis and unnecessary treatment.关键词
乳头肿瘤/浸润性汗管瘤样腺瘤/免疫组织化学/鉴别诊断Key words
nipple neoplasms/ infiltrating syringomatous adenoma/ immunohistochemistry/ differential diagnosis引用本文复制引用
孙琦,吴鸿雁,孟凡青,章宜芬,王景美..乳头浸润性汗管瘤样腺瘤临床病理分析[J].国际病理科学与临床杂志,2012,32(3):216-221,6.基金项目
南京市医学科技发展专项资金项目(QYK11164). （QYK11164）
