广西医科大学学报2012，Vol.29Issue(3)：342-344,3.
CD4+CD25+T细胞在实验性重症肌无力中的作用研究
MECHANISM OF PERIPHERAL IMMUNOTOLERANCE DISORDER IN EAMG MICE
摘要
Abstract
Objective: To study the mechanisms of peripheral immunotolerance disorder in EAMG mice. Methods: The level of CD4 CD25 Treg in CD4 splenocyte and expression of Foxp3 mRNA in splenocytes of MG symptom group and no MG symptom group were tested and compared with control group. Results: Compared -with no MG symptom group, CFA group and control group, the level of CD4 CD25 Treg of MG symptom group -was decreased in splenocytes, expression of Foxp3 mRNA of MG symptom group -was decreased in splenocytes. Conclusion: EAMG mice are deficient in peripheral tolerance, which may be involved in the development of disease.关键词
EAMG/CD4+CD25+调节性T细胞/Foxp3Key words
EAMG/ CD4 CD25 Treg/ Foxp3分类
医药卫生引用本文复制引用
李劲频,刘竞丽,莫雪安,孙圣刚..CD4+CD25+T细胞在实验性重症肌无力中的作用研究[J].广西医科大学学报,2012,29(3):342-344,3.基金项目
广西科学基金资助项目(No.桂科青0728071) （No.桂科青0728071）
