广西医科大学学报2012，Vol.29Issue(3)：364-367,4.
DNA修复基因XPA在非小细胞肺癌中的表达及其临床意义
THE EXPRESSION OF DNA REPAIR GENE XPA IN ADVANCED NON-SMALL CELL LUNG CANCER AND ITS CLINICAL SIGNIFICANCE
摘要
Abstract
Objective: To investigate the association between the expression of DNA repair gene XPA with the clinicopathology characteristics in patients with advanced non-small cell lung cancer (NSCLC) and its clinical significance. Methods: The expression of XPA -was examined -with immunohistochemistry (IHC) , the positive expression rate of XPA in different clinicopathology characteristic groups -was analyzed. Re-sultS: In 109 patients with NSCLC, the positive rate of XPA was 55. 0% (60/109) , and the expression rate in males was significantly higher than that in females (61. 0% vs. 37. 0%, P = 0. 030). The expression rate -was also higher in smokers than in non-smokers (68. 1 % vs. 45. 2% , P =0. 017). There -were no significant differences in the expression of XPA among different ages, TNM stages, and pathological classification ( P >0. 05 for all). Conclusion: In NSCLC cases, the expression status of XPA is markedly associated with gender and smoking status. Thus, XPA may play a potential role in non-small cell lung cancer occur process.关键词
非小细胞肺癌/XPA/免疫组织化学/表达Key words
non-small cell lung cancer/ xeroderma pigmentosum group A/ immunohistochemistry/ expression分类
医药卫生引用本文复制引用
覃芳卉,刘志辉,谢伟敏,廖小莉,姚铠涛,王洪学,房亮,陆永奎,周文献,胡晓桦..DNA修复基因XPA在非小细胞肺癌中的表达及其临床意义[J].广西医科大学学报,2012,29(3):364-367,4.基金项目
国家自然科学基金资助项目(No.30960436) （No.30960436）
广西自然科学基金资助项目(No.桂科自0832234) （No.桂科自0832234）
广西医疗卫生重点课题(No.重200967) （No.重200967）
