广西医学2012，Vol.34Issue(10)：1282-1284,3.
51例壮族矽肺患者TGF-β1-C-509T位点多态性与矽肺易感性的logistic回归分析
Logistic Regression Analysis of Silicosis Susceptibility and TGF-β1-C-509T Polymorphism in 51 Silicosis Patients of Zhuang Nationality
摘要
Abstract
Objective To explore the influence of transforming growth factor( TGF )-β1-C-509T polymorphism on Zhuang population suffered from silicosis. Methods Fifty eight dust exposure workers of Zhuang nationalityC dust exposure group ) and 51 silicosis cases of Zhuang nationalityC silicosis group ) were randomly enrolled in the study. The TGF-β1-C-509T polymorphism was detected by polymerase chain reaction restriction fragment length polymorphism ( PCR-RFLP) technique in the two groups. Data about smoking were collected among all the subjects, and logistic regression analysis was performed. Results Compared with silicosis group,the cases of genotype TT at TGF-β1-C-509T locus were more easily suffered from silicosis than those of genotype CC in dust exposure group. But no significant difference was found in the prevalence of silicosis between smokers and non-smokers( P >0.05 ). Conclusion TGF-β1-C-509T locus of genotype CC may be the protective factor of silicosis in Zhuang population.关键词
矽肺/TGF-β1/C-509T位点多态性/logisic回归分析/壮族Key words
Silicosis/Transforming growth factor-β1/G-509T locus polymorphism/Logistic regression analysis/ Zhuang nationality分类
医药卫生引用本文复制引用
周武旺,黄小琪,陈晶,陈志强,卢雪梅,何雪明,李荣娟..51例壮族矽肺患者TGF-β1-C-509T位点多态性与矽肺易感性的logistic回归分析[J].广西医学,2012,34(10):1282-1284,3.基金项目
广西自然科学基金(2010GXNSFA013234) （2010GXNSFA013234）
