广西植物2012，Vol.32Issue(3)：392-399,8.DOI:10.3969/j.issn.1000-3142.2012.05.022
新型大豆异黄酮磺酸酯的临床前药物动力学
Pre-clinical pharmacokinetics of novel soybean iosflavone sulfonate
摘要
Abstract
The oral bioavailability of genistein (GE) in its benzensulfonate prodrug was studied in search for its novel prodrug.The plasmas were collected at different points of time after the intragastric or intravenous administration of genistein benzensulfonate (GBS) 40 mg/kg to rats.The GBS and GE contents in plasma were determined by HPLC.The compartment model was fitted and pharma cokinetic parameters were calculated by DAS 2.1.1.The results indicated that the dynamic processes of GE were consistent with two compartment model after intragastric administration of GBS prodrug to rats.The relative oral bioavailability of GE in prodrug GBS was 198.6％.In conclusion,the above results demonstrated that the oral bioavailability of GE in prodrug had been improved remarkably.关键词
染料木素磺酸酯/前药/药物动力学/生物利用度Key words
genistein sulfonate/ prodrug/ pharmacokinetics/ bioavailability分类
医药卫生引用本文复制引用
彭游,陶春元,邓泽元..新型大豆异黄酮磺酸酯的临床前药物动力学[J].广西植物,2012,32(3):392-399,8.基金项目
Supported by the National Natural Science Foundation of China(81160412) （81160412）
the Natural Science Foundation of Jiangxi Province (2010GZN0106) （2010GZN0106）
the Science and Technology Item of the Education Department of Jiangxi Province(GJJl1626) （GJJl1626）
