广州化学2012，Vol.37Issue(2)：52-63,12.
AChE抑制剂类抗AD药物的研究进展
Research Progress of Acetylcholinesterase Inhibitors in the Treatment of Alzheimer＇s Disease
杨焱焱 1蒋玉仁1
作者信息
- 1. 中南大学化学化工学院,湖南长沙410083
- 折叠
摘要
Abstract
Alzheimer＇s disease （AD） is a common neurodegenerative disorder, and it is characterized by a neurochemically shortage of cholinergic neurotransmission. Additionally, AChE inlaibitors plays a key role not only in improving cholinergic nerve function, but also slowing down the aggregation of β-amyloid and the formation of the neurotoxic fibrils in the brain. AD could be treated by the agents which can increase the level of acetylcholine （ACh） via the inhibiting acetylcholinesterase （ACHE）. At present, studies of AChE inhibitors are mainly focused on drugs of AChE inhibitors （such as tacrine, donepezil, galantamine, huperzine） and natural products （especially the plant origin and microbialsource）, and also their derivatives.关键词
阿尔茨海默氏病/乙酰胆碱酯酶抑制剂/生物碱/萜类/木质素Key words
Alzheimer's disease/acetylcholinesterase inhibitors/alkaloids/terpenoids/lignin分类
医药卫生引用本文复制引用
杨焱焱,蒋玉仁..AChE抑制剂类抗AD药物的研究进展[J].广州化学,2012,37(2):52-63,12.
