加味酸枣仁汤对慢性应激抑郁模型大鼠脑组织单胺类神经递质NE、DA及5- HT影响的实验研究OACSTPCD
Effects of Modified Suanzaoren Decoction on Monoamine Neurotransmitters ( NE, DA and 5 - HT) of Rats with Depression
目的:探讨加味酸枣仁汤对慢性应激抑郁模型大鼠脑内单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)及5-羟色胺(5-HT)的影响.方法:采用孤养法结合慢性不可预见性温和应激制备大鼠抑郁模型,用荧光法测定大鼠脑内单胺类神经递质的含量,运用统计学方法比较组间差异,说明加味酸枣仁汤对抑郁动物模型的影响.结果:模型对照组大鼠脑内单胺类神经递质含量与正常对照组有显著差异,加味酸枣仁汤高剂量组可显著提高抑郁大鼠脑内单胺类神经递质含量.结论:加味酸枣仁汤可增加…查看全部>>
Objective: To investigate the effect of modified Suanzaoren decoction on the monoamine neurotransmitters ( NE, DA and 5 -HT) of rats with depression. Methods : Isolatetd -living condition and chronic mild unpredictable stress are applied successively to set up DEP rat model. Fluorometric method is applied to detect the monoamine neurotransmitters ( NE ,5 -HT and DA) of the brains. To e-valuate the efficiency of modified Suanzaoren decoction on the depressive…查看全部>>
封倩;冯来会;杨新年
郑州人民医院,河南郑州 450003郑州人民医院,河南郑州 450003河南中医学院,河南郑州 450008
医药卫生
加味酸枣仁汤抑郁症单胺类神经递质去甲肾上腺素多巴胺5-羟色胺
modified suanzaoren decoctiondepressionmonoamine neurotransmiltersnoradrenalinedopamine5 - HTA
《中医学报》 2012 (5)
581-582,2
河南省科技攻关项目(编号:0423032200)
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