核化学与放射化学2012，Vol.34Issue(2)：74-82,9.
正电子核素标记奥曲肽类似物的研究进展
Progress of Octreotide and Their Analogues Labeled With Positron Radionuclides
郭飞虎 1刘婷 2陈玉清 3赵贵植 1陈大明 1杜进1
作者信息
- 1. 中国原子能科学研究院同位素研究所,北京102413
- 2. 原子高科股份有限公司,北京102413
- 3. 环境保护部核与辐射安全中心政策法规研究所,北京100082
- 折叠
摘要
Abstract
As a kind of artificially synthesized somatostatin analogues containing eight amino acids, octreotide can specificially bind with somatostatin receptor (SSTR) which is usually over-expressed on many tumor cells. So it may have important clinic significance'to use octreotide and their analogues labeled with positron radionuclides as the tumor probes for the diagnosis and treatment of SSTR positive tumor. This review provides a critical and thorough overview of the development of octreotide and their analogues labeled with positron emitting nuclides and the in vivo evaluation of PET radiopharmaceuticals that have emerged so far along with their possible applications in nuclear medicine.关键词
生长抑素(SST)/生长抑素受体(SSTR)/奥曲肽/正电子发射计算机断层显像(PET)/肿瘤诊断Key words
somatostatin (SST)/ somatostatin receptor (SSTR) / octreotide/ positron emission computed tomography (PET)/ tumor diagnosis分类
医药卫生引用本文复制引用
郭飞虎,刘婷,陈玉清,赵贵植,陈大明,杜进..正电子核素标记奥曲肽类似物的研究进展[J].核化学与放射化学,2012,34(2):74-82,9.
