基础医学与临床2012，Vol.32Issue(6)：669-672,4.
术前单用静脉铁剂对胃肠肿瘤相关性贫血的治疗作用
The effectiveness of preoperative intravenous iron alone in patients of gastrointestinal tumor with anemia
摘要
Abstract
Objective To evaluate the effectiveness and security of preoperative intravenous iron alone in patients of gastrointestinal tumor with anemia and find out the validity to reduce the perioperative blood transfusion. Methods To collect the information of patients with preoperative anemia admitted to Beijing Union Medical College Hospital From June, 2010 to February, 2012 for gastrointestinal tumor. Patients with iron deficiency anemia were treated with intravenous iron. In the morning of operation or 14th day after treatment, the blood routine test, serum iron, ferritin, transferrin protein, liver and kidney function tests were performed. Perioperative blood transfusion dose of those subjects was compared with that of the same period of hospitalization in patients with anemia. Results A total of 121 patients entered and completed the study, in which 13 cases of gastrointestinal stromal tumor, 59 cases of gastric cancer and 49 cases of colorectal cancer. Application of preoperative intravenous iron improved hemoglobin level rapidly, and also increased red blood cell count. MCV, MCHC and MCH which are indicators of red blood cell were improved after treatment. Shortly after intravenous iron treatment, serum iron and serum ferritin levels were significantly increased compared with that before treatment (P < 0. 05). And the patients with a hemoglobin levels before treatment < 100 g/L had a better response to intravenous iron compared to which with pre-treatment hemoglobin level≥100 g/L. Iron treatment can reduce the perioperative transfusion of red blood cell dose compared with the non treatment anemia patients with cancer(P < 0. 05). Conclusions In the gastrointestinal cancer patients with pre-treatment anemia, intravenous iron alone can increase the hemoglobin, decrease the iron deficiency of preoperative anemia patients safely and rapidly, and can reduce perioperative blood transfusion. The efficacy of intravenous iron may be affected by the degree of anemia.关键词
消化道恶性肿瘤/肿瘤相关性贫血/缺铁性贫血/静脉铁剂Key words
gastrointestinal tumors/ cancer-related anemia/ iron deficiency anemia/ intravenous iron分类
医药卫生引用本文复制引用
马志强,葛军娜,于健春,康维明,孟庆彬,叶欣..术前单用静脉铁剂对胃肠肿瘤相关性贫血的治疗作用[J].基础医学与临床,2012,32(6):669-672,4.基金项目
科技部国家科技支撑计划(2008BAI58B02) （2008BAI58B02）
卫生部第四届中央保健课题基金(B2009A094) （B2009A094）
国家高技术研究发展计划项目(863项目) （863项目）
北京市卫生局医疗卫生科技成果和适宜技术推广项目(TG2009-3) （TG2009-3）
