基础医学与临床2012，Vol.32Issue(6)：678-681,4.
ACE2在高血压大鼠左心室重构中的作用及缬沙坦干预的作用
The role of ACE2 in ventricular remodeling and effect of valsartan treatment on the spontaneously hypertensive rats
摘要
Abstract
Objective To investigate the expression of angiotensin converting enzyme 2 (ACE2) in the SHR,and the effect of valsartan on the expression of ACE2 mRNA. Methods Twenty-four Twelve-week-old male SHR were randomly divided to SHR group and valsartan group; Twelve-week-old male Wistar rats were served as control group. After 10 weeks, determine the heart weight index and the 1 eft ventricular weight index; determine the concentration of Ang Ⅱ in plasma by ELISA; determine the hydroxyproline content in myocardium by buck solution; The expression of ACE2 mRNA in myocardium was measured by RT-PCR. Results Compared with the control group, the LVWI, the hydroxyproline content and the concentration of Ang Ⅱ were significantly increased in the SHR group,but the ACE2 expression was markedly decreased; compared with SHR group, the above indexes were decreased except for ACE2 was increased in valsartan group. Conclusions Valsartan can reverse left ventricular re-moding in hypertension. The possible mechanism is that valsartan can incerease the expression of ACE2.关键词
血管紧张素转换酶2/左心室重构/缬沙坦/自发性高血压大鼠Key words
angiotensin converting enzyme 2/ vascular remoding/ valsartan/ spontaneously hypertensive rats分类
医药卫生引用本文复制引用
房灿,孙经武,刘成霞,刘冉冉..ACE2在高血压大鼠左心室重构中的作用及缬沙坦干预的作用[J].基础医学与临床,2012,32(6):678-681,4.基金项目
山东省医药科技发展计划(2009HW008) （2009HW008）
