昆明医学院学报2012，Vol.33Issue(5)：82-86,97,6.
代谢综合征与轻度认知功能障碍的临床研究
Clinical Study on Relationship between Metabolic Syndrome and Mild Cognitive Impairment
摘要
Abstract
Objective To investigate the relationship between metabolic syndrome (MS) and mild cognitive Impairment (MCI) . Methods 124 clinical MS subjects for research group, and 71 non- MS for control, who matched in age, sex and education. According to MCI diagnostic standards of Petersen, all cases were selected into the MCI group and cognitive function normal group (NC group) . With each metabolic abnormalities, MS subjects were scored 1 point and divided into five groups according to scores 0 ～1, 2, 3, 4, 5. Results (1) MCI incidence in MS was higher than in non-MS (P<0.01). The higher metabolic score in MS, the higher MCI incidence (P<0.01) . (2) Indicators of metabolic abnormalities in MCI were serious thants in NC (P<0.05) , and ISI is lower than in NC (P<0.05). (3) Scores of MMSE, MoCA, CMS and its componen in MS were lower than in non-MS (P<0.05). (4) Multivariate regression and logistic regressive analysis showed that all scores about cognition (except for Image Free Recall) were correlated negatively with MS, and with FIN (except for Point To Memory, Memories Of Portrait Features) . Scores of MMSE and MoCA were correlated negatively with blood pressure. The relationship still remains while diadetes patients were excluded, but the scores above were not correlated with FIN. (5) Education, insulin resistance and MS eventually enter the logistic equation (the regression coefficients are - 0.460 /0.855 /1.289) . Conclusion (1) MS impacts on various aspects of the cognitive function. Impacting on mild cognitive, MS as a whole is greater than the function of each component. (2) High level of education is a protective factor for MCI , and MS and insulin resistance is independent risk factor for MCI.关键词
代谢综合征/轻度认知功能障碍/胰岛素抵抗/危险因素Key words
Metabolic syndrome/ Mid cognitive impairment/ Insulin resistance/ Risk factor分类
医药卫生引用本文复制引用
赵晓红,杨玉梅,鲍娟,王曦,张媛媛,赵青..代谢综合征与轻度认知功能障碍的临床研究[J].昆明医学院学报,2012,33(5):82-86,97,6.基金项目
云南省科技厅应用基础研究面上基金资助项目(40209023) （40209023）
