昆明医学院学报2012，Vol.33Issue(6)：13-17,5.
云南汉族人群VKORC11173C/T基因多态性与华法林抗凝治疗维持剂量的相关性研究
Relationship between Genetic Polymorphism of VKORC1 1173C/T and Warfarin Dose Requirments in Yunnan Han Population
摘要
Abstract
Objective To investigate the polymorphism distribution and characteristics of VKORC1 1173C/T, as well as the relationship between the polymorphism and warfarin dose requirments in Han population in Yunnan. Methods Blood samples were collected from 300 patients with stable warfarin dose requirements, PCR-RFLP techniques were used to detect genes and genotypes of VKORC1 1173C/T, and international normalized ratio (INR) of the prothrombin time within the target range (1.5-3.0) , polymorphisms for VKORC 1 1173C/T were also analyzed. Results We obtained two alleles of C and T, with the frequencies of 10% and 90% , respectively. The genotypes showed that 80% patients were homozygous TT; and 20% were heterozygous CT. No differences were found between age and gendre. Patients with CT genotypes required higher warfarin dose (3.62 ± 1.35 mg/day) than those with TT (3.12 ± 1.17 mg/day; CT:TT p = 0.007). Conclusion VKORC1 1173C/T gene distribution in Yunnan Han is different from those in other populations, and some suggestions are given for individual use of warfarin in Yunan Han population.关键词
云南地区/汉族/华法林/VKORC1/基因多态性Key words
Yunan/ Han/ Warfarin/ VKORC1/ Genetic polymorphism分类
药学引用本文复制引用
刘建兴,陈智豫,李云萍,王通,吴春婷,李贺,许冰莹..云南汉族人群VKORC11173C/T基因多态性与华法林抗凝治疗维持剂量的相关性研究[J].昆明医学院学报,2012,33(6):13-17,5.基金项目
国家自然科学基金资助项目(30860339),云南省社会发展科技计划项目(2009ZC155M) （30860339）
