昆明医学院学报2012，Vol.33Issue(6)：66-69,4.
血IL-10、IL-5、IL-2、IFN-γ水平在反复腹痛患儿及其家庭成员中的比较
Plasma Level of IL-10,IL-5,IL-2 and IFN-γ in the Family Members of Children with Recurred Abdominal Pain
摘要
Abstract
Objective To understand the level of IL-10, IL-5, IL-2 and IFN- γ in the family members of children with recurred abdominal pain. Methods The venous EDTA blood specimen (3 mL/one) were obtained from 89 family members of 16 children under 3 to 14 years old with recurred abdominal pain for investigating the level of IL-10, IL-5 , IL-2 and IFN- γ by ELISA. The family members were divided into three groups: children with recurrent abdominal pain, family adult members with recurrent abdominal pain and adults without recurrent abdominal pain. Results The levels of IL-10 and IL-5 were lower in family children and adult members with recurrent abdominal pain than adults without recurrent abdominal pain ( (F10 = 26.77, P < 0.01; F5 = 23.92, P < 0.01). The levels of IL-2 and IFN- γ were higher in in family children and adult members with recurrent abdominal pain than adults without recurrent abdominal pain ( (F2 =25.03, P <0.01; FIFN-γ =21.50, P < 0.01) ). Conclusion The lower levels of IL-10 and IL-5 in family children and adult members with recurrent abdominal pain suggest the poor anti-inflammtory abilities (poor Th2 function). The high levels of IL-2 and IFN- γ in family children and adult members with recurrent abdominal pain suggest the productive and active inflammtory responses (productive Thl function).关键词
腹痛/患儿/家庭/成员/细胞因子Key words
Abdominal pain/ Children/ Family/ Members/ Cytokines分类
医药卫生引用本文复制引用
周义忠,颜如,刘梅,赵亚玲,丁臻博,黄永坤..血IL-10、IL-5、IL-2、IFN-γ水平在反复腹痛患儿及其家庭成员中的比较[J].昆明医学院学报,2012,33(6):66-69,4.基金项目
云南省自然科学研究基金资助项目(2009CD163) （2009CD163）
