昆明医学院学报2012，Vol.33Issue(6)：88-91,4.
趋化因子受体CXCR4在颅咽管瘤中的表达及其与预后的关系
Expression of CXCR4 in Craniopharyngiomas and Its Correlation with Prognosis
摘要
Abstract
Objective To investigate the expression of CXCR4 in craniopharyngiomas and observe the relation between the expression and the recrudescence of craniopharyngiomas. Methods 40 adamantine craniopharyngioma (ACP) patients and 40 squamous craniopharyngioma (SCP) patients were enrolled in this study, and each group was then divided into recurrence group and recurrence-free group. The expression of CXCR4 was evaluated in each group by immunohistochemical method (avidin-biotin-peroxidase). Results 14of 40 ACP patients and 6 of 40 SCP patients had recurred during follow-up. CXCR4 expression and recurrence rate showed significant difference between ACP group and SCP group (P <0.05). CXCR4 expression between recurrence group and recurrence-free group was significantly different (P < 0.05). Conclusion The subtype and CXCR4 expression in craniopharyngiomas are related to the prognosis of tumor and thus may be useful in predicting the risk of tumor relapse.关键词
颅咽管瘤/CXCR4/预后/免疫组织化学Key words
Craniopharyngioma/ CXCR4/ Prognosis/ Immunohistochemistry分类
医药卫生引用本文复制引用
刘健刚,陈乾,周良学,徐建国,游潮..趋化因子受体CXCR4在颅咽管瘤中的表达及其与预后的关系[J].昆明医学院学报,2012,33(6):88-91,4.基金项目
深圳市科技计划基金资助项目(201003153) （201003153）
