摘要
Abstract
Objective To study immune function changes in patients with immune thrombocytopenic purpura patients after laparoscopic splenectomy. Methods 16 patients who underwent laparoscopic splenectomy for ITP from June 2006 to June 2008 were followed up, and the laboratory indexes of immune function pre-and post-splenectomy were tested and compared. The laboratory indexes included cell-mediated immunity (detection of T cell subsets) , humoral immunity (detection of immunoglobulins IgG, IgA, IgM and complement C3, C4) , and routine blood test. Results The plasma concentration of IGG, IGA, C3, the lymphocyte counts, the subsets of CD3, CD4 and CD8 post-splenectomy were higher than pre-splenectomy (P < 0.05) , the change of IgM, C4 and the ratio of CD4/CD8 was not statistically significant. Conclusions For patients with immune thrombocytopenic purpura who underwent laparoscopic splenectomy, immune function has not been declined, but has been improved. Therefore, if hormone therapy is ineffective, patients with ITP should actively consider laparoscopic splenectomy.关键词
免疫性血小板减少性紫癜/腹腔镜脾切除术/免疫功能Key words
Immune thrombocytopenic purpura/ Immune thrombocytopenic purpura/ Immune function分类
临床医学
