兰州大学学报（医学版）2012，Vol.38Issue(2)：67-72,6.
组蛋白乙酰化修饰与神经发生
Histone acetylation and neurogenesis
摘要
Abstract
Epigenetics is the reversible changes in gene expression without the changes of DNA sequences, which include DNA methylation, histone modification and non-coding RNA expression and so on. Histone acetylation is the earliest studied posttranslational modification of epigenetic regulations. The results suggest that histone acetylation plays an important role in the neurogenesis. Neurogenesis (birth of neurons), the process by which neurons are generated from neural stems and progenitor cells, is responsible for populating the brain neurons growth and plays a key role in the development of the central nervous system and neurodevelopmental disorders. Data show that genetic and environmental factors participate in the regulation of neurogenesis included in epigenetics. It is very important to clarify the histone acetylation regulation on neurogenesis in order to provide a theoretical basis to repair the damage of central nervous system, and to treat the neurodegenerative diseases and developmental disorders of central nervous system.关键词
表观遗传学/组蛋白乙酰化/神经发生Key words
epigenetics/ histone acetylation/ neurogenesis分类
医药卫生引用本文复制引用
宋玫香,王小琦,包金风..组蛋白乙酰化修饰与神经发生[J].兰州大学学报（医学版）,2012,38(2):67-72,6.基金项目
徐州市科技局基金(XM0913115) （XM0913115）
