临床神经病学杂志2012，Vol.25Issue(2)：81-84,4.
新疆地区维、汉族缺血性脑卒中患者磷酸二酯酶4D基因单核苷酸多态性的研究
Investigation on the single-nucleotide polymorphism of phosphodiesterase 4D gene in Uygur and Han patients with ischemic stroke in Xinjiang district
摘要
Abstract
Objective To investigate the single-nucleotide polymorphism ( SNP) in 87 site of phosphodiesterase 4D (PDE4D) gene in Uygur and Han patients with ischemic stroke in Xinjiang district. Methods The gene polymorphism of 87 site of PDE4D gene in 226 patients with ischemic stroke ( case group, 110 cases of Uygur, 116 cases of Han) and 220 patients without neurological disease (control group, 102 cases of Uygur, 118 cases of Han) were detected by PCR restriction fragment length polymorphism (PCR-RFLP) and gene sequencing method. The genotype and allele frequency of all the groups were compared with each other. Results There was no significant difference of genotypes of PDE4D gene 87 site between the case group and the control group. The C allele frequency in case group was significantly higher than that in the control group ( P < 0. 05). The CC genotype and C allele frequency in Uygur subgroup of case group were obviously higher than that in Uygur subgroup of control group (all P <0. 05) ; and the CC genotype and C allele frequency in Han subgroup of case group were obviously higher than that in Han subgroup of control group (all P < 0. 05). In the case group, there was no significant difference of PDE4D gene 87 site genotypes and allele frequency between Uygur subgroup and Han subgroup. And in the control group, there was no significant difference of PDE4D gene 87 site genotypes and allele frequency between Uygur subgroup and Han subgroup. Conclusions The increase of C allele frequency of PDE4D gene 87 site may increase the risk of ischemic stroke. And the risk is not different between Uygur and Han population in Xinjiang district.关键词
磷酸二酯酶4D基因/单核苷酸多态性/缺血性脑卒中Key words
phosphodiesterase 4D gene/ single-nucleotide polymorphism / ischemic stroke分类
医药卫生引用本文复制引用
张小宁,杜合宾,王静,马建华..新疆地区维、汉族缺血性脑卒中患者磷酸二酯酶4D基因单核苷酸多态性的研究[J].临床神经病学杂志,2012,25(2):81-84,4.基金项目
国家自然科学基金(81060097) （81060097）
