摘要
Abstract
Objective To approach the effects of Rosuvastatin calcium on blood lipids and carotid artery atherosclerotic in patients with transient ischemic attack (TIA). Methods Sixty-four TIA patients with carotid atherosclerosis were randomly divided into therapy group (32 cases) and control group (32 cases). On the basic of the treatment including Nimodipine, Aspirin, cytidine diphosphate choline, etc. in the 2 group, the patients in therapy group received Rosuvastatin calcium 10 mg/d for 6 months. Pre and post treatment, the levels of blood lipids were detected. The carotid intima-media thickness ( IMT) and the area of carotid atherosclerotic plaques were measured by ultrasonic. Followed-up for 6 months, the incidence of cerebrovascular disease and adverse drug reaction were record. Results The levels of blood triglyceride, cholesterol and low density lipoprotein were significantly lower, and the carotid IMT and area of plaque were significantly less at post treatment in therapy group than pre treatment and control group ( all P <0. 05) .while there was no significant difference in the control group between pre and post treatment. The incident of cerebrovascular disease (9.4% ) in therapy group was significantly lower than that in control group (37. 5% ) (X2 = 7.108, P< 0.05 ). There was no adverse reaction in the two groups. Conclusion Rosuvastatin calcium can effectively reduce the blood lipid level, improve the carotid atherosclerosis and reduce the incidence of eerebrovaseular disease.关键词
瑞舒伐他汀钙/血脂/颈动脉粥样硬化斑块/短暂性脑缺血发作Key words
Rosuvastatin calcium/ blood lipids/ carotid atheroscleroti/ transient ischemic attack分类
医药卫生
