临床神经病学杂志2012，Vol.25Issue(2)：144-146,3.
糖皮质激素治疗多发性硬化不同方案的临床应用
Clinical application of different protocols of glucocorticoids on treating multiple sclerosis
摘要
Abstract
Objective To evaluate the curative effects, the expenses and time of hospitalization, the condition of recurrence and the adverse reactions of different protocols of glucocorticoids on treating multiple sclerosis (MS). Methods Ninty-seven MS patients at acute stage were randomly divided into melhylprednisolone (MPS) intrathecal injection group (30 cases) , MPS pulse therapy group (36 cases) and dexamethasone ( DXM ) therapy group (31 cases). The decrease of Kurtzke expanded disability status scale(EDSS) at different time after treatmentand, the expenses and time of hospitalization, the proportion of drugs in hospitalization expenses, the condition of recurrence and the adverse reactions among all the groups were compared with each other. Results The decrease of EDSS in MPS intrathecal injection group scince 5 d after treatment and in MPS pulse therapy group scince 10 d after treatment were significantly higher than that in DXM therapy group (all P<0. 05). The decrease of EDSS in MPS intrathecal injection group at 5 d after treatment was significantly higher than that in MPS pulse therapy group (P < 0.05). Among the three groups, the total expense of hospitalization and the proportion of drugs in hospitalization expenses were the least in MPS intrathecal injection group, and the daily mean expense of hospitalization was little, ihe hospitalization time was short (all P<0.05). The daily mean expense of hospitalization was the most in MPS pulse therapy group, and the hospitalization time was the longest in DXM therapy group (all P<0.05). The recurrence rate was the highest and the recurrence time was the shortest in MPS pulse therapy group (all P < 0. 05). The difference of recurrence rate and time was no statistical significance between MPS intrathecal injection group and DXM therapy group. There was no severe adverse reaction in all the groups. Conclusions The curative effect of MPS intrathecal injection on treating MS is fast and significant in short-term with little hospitalization expense, low recurrence rate and long recurrence time. It has no severe adverse reaction, and is suitable to be generalized in clinic.关键词
多发性硬化/糖皮质激素/鞘内注射Key words
multiple sclerosis/ glueocorticoids/ intrathecal injection分类
医药卫生引用本文复制引用
董艳玲,李吕力,李瑶宣,梁浩,滕晓茗,肖继东,张德敏..糖皮质激素治疗多发性硬化不同方案的临床应用[J].临床神经病学杂志,2012,25(2):144-146,3.基金项目
广西科学研究与技术开发计划课题(桂科攻0898010) （桂科攻0898010）
广西壮族自治区卫生厅科研课题(Z2008085) （Z2008085）
