摘要
Abstract
Objective To evaluate the literature of the efficacy and safety of Penehyclidine Hydrochloride and Atropine in the treatment of acute organophosphorus pesticide poisoning in China. Methods We retrieved Weipu Chinese Technology Periodicals, WanFang Medical Databanks and CNKI during January 2000 and December 2010 for comparative study on the efficacy of the Penehyclidine Hydrochloride and Atropine in the treatment of acute organophosphorus pesticide poisoning. We also used Peter literature quality assessment system to assess the literature quality. Statistical Software Rev Man 5.0 was used for Meta-analysis. Results The 6 records for indexes included 480 cases, the experimental group ( Penehyclidine Hydrochloride group, n =229) and the control group (Atropine group, n = 251). 6 papers of the literature were of medium or high qualtiy. There was no significant difference in baseline information. Meta-analysis showed that the recovery rate of the experimental group was higher than that of the control group [14% , RR = 1. 14, 95% CI(1.08, 1.20) , P<0. 00001]]. The average hospital stay was 4.45 days shorter than thai of the control group [MD= -4.45,95%CI ( -6.56, -2.35), P<0.0001]. The incidence rate of adverse reactions decreased by 92% compared with that of the control group [ RR = 0.08, 95% CI (0.04, 0.15), P < 0.00001]. Conclusion Treatment of acute organophosphorus pesticide poisoning with penehyclidine Hydrochloride is better than Atropine existing clinical evidence. As the sample capacity available for analysis is limited, more cases of large randomized controlled clinical trials are needed to further validate the results of it.关键词
有机磷化合物/中毒/盐酸戊乙奎醚/阿托品/Meta分析Key words
Organophosphorus compound/ Poisoning/ Penehyclidine hydrochloride/ Atropine/ Meta-analysis分类
医药卫生
