临床与实验病理学杂志2012，Vol.28Issue(8)：870-873,4.
前列腺癌骨转移灶中BMP-2、BMP-4、BMP-7的表达及临床意义
Expression of BMP-2, BMP-4 and BMP-7 in human metastatic prostate cancer and their clinical significance
宫丽华 1孙晓淇 1刘宝岳 1黄啸原1
作者信息
- 1. 北京积水潭医院病理科,北京,100035
- 折叠
摘要
Abstract
Purpose To analyze the expression of BMP-2, BMP-4, BMP-7 in prostate cancer with bone metastasis. Methods Iininu-nohistochemical technique was used to detect the expression of BMP-2, BMP-4 and BMP-7 in the bone osteobastic metastastic lesions of prostate cancer and the benign prostate hyperplasia ( BPH ). Results The expression of BMP-2 was detected in all samples and there was no difference between prostate cancer and BPH. The intensity of positivity of BMP-4 was higher in prostate cancer than that in BPH ( P < 0. 05 ), but the difference of positive rate between these two groups showed no significance. The intensity of positivity and the positive rate of BMP-7 were higher in prostate cancer than that in BPH ( P < 0. 05 ). The positive rate of staining involving both cyto-plasm and nuclear in BMP-2, BMP-4 and BMP-7-positive samples in BPH was respectively 13. 3% , 7. 1% and 11. 1% , respectively, but these in prostate cancer were all 100% , in which the intensity of nuclear staining was higher than that of cytoplasm. Conclusions The expression of BMP-4 and BMP-7 in the prostate cancer with bone osteobastic metastasis is higher than that in the BPH, which implies that they may play an important role in osteobastic metastasis of prostate cancer.关键词
前列腺肿瘤/骨转移/BMP-2/BMP-4/BMP-7Key words
prostate neoplasms/ bone metastasis/ BMP-2/ BMP-4/ BMP-7分类
医药卫生引用本文复制引用
宫丽华,孙晓淇,刘宝岳,黄啸原..前列腺癌骨转移灶中BMP-2、BMP-4、BMP-7的表达及临床意义[J].临床与实验病理学杂志,2012,28(8):870-873,4.
