临床与实验病理学杂志2012，Vol.28Issue(8)：883-886,4.
肾源性腺瘤临床病理和免疫组化分析
Nephrogenic adenoma: clinicopathological and immunohistochemical analyses
摘要
Abstract
Purpose To analyze the clinicopathological and immunohistochemical features of nephrogenic adenoma ( NA ) in the urinary tract. Methods Five cases of nephrogenic adenoma in the urinary bladder and ureter were evaluated by histopathology and iminuno-histochemistry with review of the literature on its etiology, pathogenesis, and clinicopathological features. Results Three of the cases were from the urinary bladder and two from the ureter. The lesions appeared as a mucosal papillary or polypoid mass macroscopically, and were consisted of tubules, cysts or papillary structures lined by cuboidal, flat, or hobnail-like epithelial cells microscopically. Immunohistochemical staining showed that the epithelial cells were positive for PAX2, CK7, EMA, and AMACR/P504S, but negative for PSA, CD10, p63 and CD31. The Ki-67 labeling index was less than 2% . Conclusions Nephrogenic adenoma is a rare tumor-like lesion that may be misdiagnosed as epithelial tumors such as adenocarcinoma. Awareness of the entity and familiarity with its clinicopathological and immunohistochemical features are the keys to the correct diagnosis.关键词
肾源性腺瘤/膀胱肿瘤/输尿管肿瘤/免疫组织化学Key words
nephrogenic adenoma/ urinary bladder neoplasms/ ureter neoplasms/ immunohistochemistry分类
医药卫生引用本文复制引用
陈铌,陈雪芹,徐苗,聂玲,李星斓,李秋尧,余天平,周桥..肾源性腺瘤临床病理和免疫组化分析[J].临床与实验病理学杂志,2012,28(8):883-886,4.基金项目
国家自然科学基金(31071134、81101529)、教育部博士点专项基金(20100181110019、20110181120021) （31071134、81101529）
