中国临床保健杂志2012，Vol.15Issue(2)：147-149,3.DOI:10.3969/J.issn.1672-6790.2012.02.013
强化他汀治疗对不稳定型心绞痛患者血清超敏C反应蛋白及可溶性CD40配体L的影响
The impact of intensive statin therapy on stability of coronary plaques in unstable angina patients
王修卫 1马立学 1韩增雷 1曹庆博 1袁涛1
作者信息
- 1. 山东青岛市第八人民医院心内科,266100
- 折叠
摘要
Abstract
Objective To investigate the clinical effect and significance of intensive statin on serum hs-CRP and soulable CD40L in unstable angina (UA) patients. Methods 130 UA patients were randomly divided into three groups. The control group (ra = 30) was given the routine medicine,and the other two therapy groups were administered rosuvastatin with 10 mg (groupl) or 20 mg (group2) qd for 8 weeks. Levels of serum hs-CRP, sCD40L and lip-id, and the incidences of major adverse cardiovascular events were determined before and after treatment. Results Compared with the control group,the levels of serum hs-CRP,CD40L,LDL-C and the rate of angina attacks were significantly decreased in treatment group 1 and group 2 (n = 50, P < 0. 05). There was significant difference between groupl ang group2 (P < 0. 01). Conclusion Intensive treatment of rosuvastatin is beneficial for UA patients. The possible mechanisms include anti-inflammation,improving the endothelium and stabilizing of plaque.关键词
心绞痛,不稳定型/C反应蛋白质/CD40配体Key words
Angina,unstable/C-reactive protein/CD40 ligand分类
医药卫生引用本文复制引用
王修卫,马立学,韩增雷,曹庆博,袁涛..强化他汀治疗对不稳定型心绞痛患者血清超敏C反应蛋白及可溶性CD40配体L的影响[J].中国临床保健杂志,2012,15(2):147-149,3.
