中国临床保健杂志2012，Vol.15Issue(2)：167-168,2.DOI:10.3969/J.issn.1672-6790.2012.02.020
血管性痴呆大鼠模型的改良
Rat model of vascular dementia improved
摘要
Abstract
Objective To evaluate the value of modified 2-vessel occlusion method (2 - VO) + SNP depres-surization production for establishing vascular dementia ( Vasculardementia,VD) rat model. Methods Bilateral common carotid artery occlusion for 20 min,reperfusion l0min for 3 times continuously, while SNP Buck. Results 2 -VO + SNP depressurization animal model of vascular dementia produced high survival rate with obvious hippocampal neurons injury and abnormal behavior. Conclusion Modified 2V0 + SNP depressurization is the ideal method of vascular dementia model.关键词
痴呆,血管性/Morris水迷宫/大鼠,Wistar/疾病模型,动物Key words
Dementia, vascular/ Morris water maze/ Rat, Wistar/ Disease models, animal分类
医药卫生引用本文复制引用
窦金金,谢宁,吴颂,史瑞,张真..血管性痴呆大鼠模型的改良[J].中国临床保健杂志,2012,15(2):167-168,2.基金项目
国家自然科学基金项目(30772719) （30772719）
